Semester of Graduation

Spring 2022


Master of Science (MS)

Document Type



The canine lungs are well suited for ventilation, gas exchange, and gas transport. In diseased states, changes within bronchi and pulmonary parenchyma alter the blood-gas interface. Diagnostic workups to characterize pulmonary disease may include blood gas analysis, bronchoalveolar lavage, tracheobronchoscopy, radiography and/or computed tomography. Surgical pulmonary diseases include cysts, bullae, and blebs; congenital anomalies; consolidation or abscessation; bronchiectasis; lacerations; lung lobe torsions; and neoplasia. Surgical options may include laceration repair, partial or total lung lobectomy, and pneumonectomy. These options are most commonly utilized in cases that fail medical management. Lung lobectomies were originally performed using suture ligation. Stapling devices have been commonly used since the 1980’s. The objectives of this study were to validate the 2.0 mm endoscopic gastrointestinal anastomosis (Endo GIA™) staple cartridge for lung lobectomies and to compare procedure time and air leakage incidence with that of suture ligation. Sixteen canine cadavers, 18-27 kilograms, were randomly assigned to total lung lobectomy of the right middle lung lobe through intercostal thoracotomy by suture ligation or the 2.0 mm Endo GIA™ staple cartridge. Procedure time was recorded. Following the lobectomy, the thoracic cavity was filled with water. Positive pressure was held at 20 cm H2O for 5 minutes. The bronchus was assessed for air leakage as evidenced by gas bubbles and the inability to maintain pressure at 20 cm H2O. Procedure time and air leakage incidence were compared between groups. The 2.0 mm Endo GIA™ staple cartridge was successful for lung lobectomies in all cadavers. There was no significant difference (t=-0.856, p=0.407) in body weight vi between groups. Procedure time was significantly shorter (p

Committee Chair

Aulakh, Karanvir