Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)


Twenty college age males participated in a weight-lifting experiment, 3 sets of 10 repetitions at 70% 1RM for the squat, to examine the time courses between creatine phosphokinase (CPK), prostaglandin F(,2) alpha metabolite (PGF(,2a) met) and ratings of perceived soreness (RPS). Both groups, aspirin (n = 10) and placebo (n = 10), received medication (3g/day) for four consecutive days, starting 1 day prior to workout. Ratings of soreness and blood samples were taken pre- and immediately post-exercise, and at 24 h intervals for 3 days after exercise. There was no significant difference (p < 0.05) between the groups for CPK and RPS across time, but the prostaglandins were significantly different (p < 0.01) at all time intervals between groups. Changes seen across time were quadratic for all variables. The 24 h prostaglandin level was significantly higher (p < 0.05) than the pre-, post-exercise and 72 h levels, but not significantly different from the 48 h level. Ratings of soreness were not significantly different (p < 0.05) at the 24 and 48 h intervals, but both were significantly higher than at all other time intervals. The mean CPK levels at 24 and 48 h were not significantly different (p < 0.05), but the 24 h CPK level was significantly higher (p < 0.05) from the other time intervals. There was a significant correlation (p < 0.01) between the time courses of CPK and RPS. It was concluded that CPK can be used as a marker for tissue damage and that prostaglandins did not influence the subjects' perception of muscle soreness or the release or uptake of CPK.