Doctor of Philosophy (PhD)



Document Type



Approaches to prepare spatially selective surfaces were developed in this dissertation for constructing assemblies of biomolecules and inorganic materials. Nanoscale surface patterns of organic thin films were prepared using particle lithography combined with organosilane chemistry. Biological and inorganic nanomaterials can be patterned with tailorable periodicities, which can be controlled by selecting the diameter of mesospheres used as surface masks. The surface platforms of well-defined nanopatterns are ideal for high resolution investigations using scanning probe microscopy (SPM). Local measurements of surface properties combined with visualization of the steps of chemical reactions at the molecular level were accomplished. Fundamental studies of the chemical steps for patterning proteins are critical for the integration of biomolecules into miniature biological-electronic devices for protein sensing. Rare earth oxide (REO) nanomaterials have useful properties such as upconversion, catalysis, and magnetism. For commercial applications REO nanomaterials should have well defined sizes and be arranged as surface arrays. Sample characterizations were accomplished with selected modes of SPM. Scanning probe studies can be used to probe the morphological and physical properties of samples, when discrete arrangements of nanomaterials are prepared. Atomic force microscopy (AFM) can be used to analyze many types of samples in ambient and liquid environments. Arrays of protein nanopatterns were fabricated using the spatial selectivity of chemical patterns prepared with particle lithography. The steps for patterning protein and protein binding were visualized with AFM. The protein arrays were tested for the selectivity of binding IgG to evaluate if protein function was retained.



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Committee Chair

Garno, Jayne C.



Included in

Chemistry Commons