Doctor of Philosophy (PhD)



Document Type



Chapter I introduced the background of phthalocyanines including its physical properties and various synthetic methods of free-base and metallo-phthalocyanines. The background of PDT and BNCT was introduced and the objective of ideal sensitizers was described. Chapter II described the synthesis and characterization of a series of pyridiloxy-substituted zinc phthalocyanines with different length of alkyl groups. Pyridiloxy-substituted silica phthalocyanines bearing different associated axial ligands, were alkylated with methyl or PEG chains. Biological study was performed on these cationic pyridiloxy-substituted zinc phthalocyanines. Chapter III introduced the synthesis and photophysical properties of A3B-type zinc phthalocyanines conjugated with one or two cobalta-carborane cages. They are highly soluble in polar solvents such as methanol, acetone, DMF and DMSO. Their absorption and emission properties are solvent-dependent, and had ~0.1 fluorescence quantum yields. These Pcs may have potential application as dual sensitizers in the PDT and BNCT treatment of tumors. Chapter IV introduced the synthesis and characterization of octa, tetra and dihdroxy-substituted phthalocyanines using different synthetic strategies. Chapter V introduced the synthesis and characterization of octaphosphonate-substituted zinc phthalocyanine.



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Committee Chair

M. Graca H. Vicente



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Chemistry Commons