Doctor of Philosophy (PhD)



Document Type



The work presented in this dissertation is a description of novel core-shell nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS) and the synthesis and characterizations of novel liposomal ionogels (LIGs). These GUMBOS are an extension of ionic liquids (ILs) which are organic salts with melting points between 25 °C and 100 °C. Ionic liquids have high thermal stability, low vapor pressure, and tunable physiochemical and functional properties. All of the properties of ILs are controlled by the chosen cation and anion pair. Similarly to ILs, GUMBOS possess the same qualities; however, they have melting points up to 250 °C. The first section is a discussion of core-shell nanomaterials composed of GUMBOS and gold. Chapter 3 is a description of the synthesis of thiol-functionalized GUMBOS and their corresponding nanoparticles (nanoGUMBOS). NanoGUMBOS were prepared using non-templated and templated methods. Non-templated nanoparticles were obtained through ionic self-assembly using a reprecipiation procedure. A reverse micellar method was utilized in the preparation of templated nanoGUMBOS. NanoGUMBOS were used as core components for the core-gold shell nanoparticles. The optical and morphological properties of nanoGUMBOS were monitored throughout the gold-coating process. Although gold-coated nanoGUMBOS have potential uses in biomedical applications, they were investigated as organic solvent sensors. In chapter 4, 1D core-shell nanoGUMBOS were prepared using a porous anodic alumina template. The corresponding optical and morphological characteristics of the nanorods were also determined along with the gold-coating procedure. With interest in electrochemical applications, cyclic voltammetry measurements were performed to determine the electronic properties of bulk GUMBOS. The second section is a description of a new type of ionogel that utilizes liposomes as the gelation matrix which we have named liposomal ionogels (LIGs). The ionogels developed in this dissertation are composed of a biocompatible IL which is prepared from choline and the amino acid proline along with dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) phospholipids. These LIGs offer two tunable components, phospholipids and ILs, and have potential as topical drug delivery tools.



Document Availability at the Time of Submission

Release the entire work immediately for access worldwide.

Committee Chair

Warner, Isiah



Included in

Chemistry Commons