Identifier
etd-04092008-140338
Degree
Doctor of Philosophy (PhD)
Department
Chemistry
Document Type
Dissertation
Abstract
Chapter 1 contains an introduction to porphyrins and carboranylporphyrins, including their physical properties, history, methods of synthesis, medicinal applications, and an overview of recently published compounds. Chapter 2 contains the total synthesis of a series of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in boron neutron capture therapy (BNCT), including characterization by proton nuclear magnetic resonance spectroscopy, matrix-assisted time-of-flight mass spectroscopy, high resolution mass spectroscopy, UV-Vis spectrophotometry, X-ray crystallography, and melting point apparatus. Chapter 3 contains synthetic methods which were investigated as alternate routes to porphyrin synthesis and functionalization. Chapter 4 presents the in vitro biological evaluation of trimethylamine- and phosphonate-substituted carboranylporphyrins.
Date
2008
Document Availability at the Time of Submission
Release the entire work immediately for access worldwide.
Recommended Citation
Easson, Michael William, "Syntheses of trimethylamine- and phosphonate- substituted carboranylporphyrins for application in boron neutron cancer therapy" (2008). LSU Doctoral Dissertations. 1887.
https://repository.lsu.edu/gradschool_dissertations/1887
Committee Chair
M. Graca H. Vicente
DOI
10.31390/gradschool_dissertations.1887