Evidence for non-inclusional association between α-cyclodextrin and polynuclear aromatic hydrocarbons

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The temperature dependence of formation constants for polynuclear aromatic hydrocarbon (PAH) complexes with cyclodextrin (CDx) has been used to determine the heat of formation (ΔHf) for the complexes. The ΔHf values are larger for α-CDx complexes than for β- and γ-CDx complexes for most PAHs, whereas the formation constant values show the opposite trend. This contradiction suggests that formation constants calculated for α-CDx-PAH complexes using the solubility method contain contributions from processes other than complexation. Together with the thermodynamic data, microenvironmental studies of pyrene within the α-CDx cavity are used to show that non-inclusional associations may contribute to the formation constants determined by solubility measurements. © 1990.

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Analytica Chimica Acta

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