Alcohol Size as a Factor in the Ternary Complexes Formed with Pyrene and β-Cyclodextrin

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The effect of alcohols on the β-cyclodextrin (CD)/pyrene complex has been examined by using steady-state fluorescence measurements. A 1:1 stoichiometric ratio has been found between the alcohol and β-CD. As the stoichiometry of the binary β-CD/pyrene complex is 2:1, a ternary complex of stoichiometry of 2:1:2 β-CD/pyrene/alcohol is proposed. Apparent formation constants in the presence of different alcohols have been determined by using the variation of the I/III vibronic band ratio of pyrene with increasing cyclodextrin concentration. The 2:1 β-CD/pyrene stoichiometry for the binary complex has also been confirmed. The present study demonstrates that proper size matching among the pyrene, the cyclodextrin, and the alcohol leads to substantially larger equilibrium constants for the ternary complexes. © 1991, American Chemical Society. All rights reserved.

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Journal of the American Chemical Society

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