Improved chiral separation using achiral modifiers in cyclodextrin modified capillary zone electrophoresis

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The influence of achiral modifiers on the chiral separation of propranolol is examined by cyclodextrin modified capillary zone electrophoresis. The improved chiral separation of propranolol is by molecules previously identified in our group as forming ternary complexes with cyclodextrin and pyrene. The polarity, chain size and heteroatom composition of the functional groups on the comodifiers was systematically varied in order to study the influence of these variables on the separation of propranolol. The improved chiral separation is accompanied by a decrease in retention time. The decrease in retention time is suggestive of a decrease in the association of β-cyclodextrin (β-CD) with propranolol which was verified by calculation of apparent association constants using fluorometric methods.

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Journal of Chromatography A

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