A selective fluorescent sensor for imaging Cu2+ in living cells
Copper ion is a biochemically essential yet toxic metal ion, connected to serious neurodegenerative diseases, and also has been identified as an environmental pollutant. For the effective detection of Cu2+ in biological and environmental systems, we have developed a new membrane-permeable Cu2+-selective water-soluble BODIPY 1, which was synthesized by nucleophilic disubstitution of novel 3,5-diiodo-BODIPY 4 with N,N-bis(2-hydroxyethyl)amines. BODIPY 1 shows a highly sensitive and selective fluorescence response to Cu2+ in aqueous solution. Fluorescence image experiments establish that 1 can be used to monitor intracellular Cu 2+ within living cells. © 2009 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Publication Source (Journal or Book title)
New Journal of Chemistry
Jiao, L., Li, J., Zhang, S., Wei, C., Hao, E., & Vicente, M. (2009). A selective fluorescent sensor for imaging Cu2+ in living cells. New Journal of Chemistry, 33 (9), 1888-1893. https://doi.org/10.1039/b906441a