Syntheses of porphyrin and chlorin dimers for photodynamic therapy (Invited Paper)

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Conference Proceeding

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Efficient methods for the syntheses of porphyrin and chlorin dimers joined with variable length carbon units, either at meso positions or at β-pyrrolic positions, are described. The in vivo testing results for some of the dimers are also discussed. The main objective of this work is to understand the structure/activity relationships among carbon-carbon linked dimers of porphyrins and chlorins. It is anticipated that this study will assist the authors in designing photosensitizers with required chemical and photochemical properties.

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Proceedings of SPIE - The International Society for Optical Engineering

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