Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy and their preliminary biological activity

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Conference Proceeding

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The chlorophyll-a degradation product, purpurin-18 methyl ester (4), was converted into a series of new bacteriochlorins (18)-(20). These stable bacteriochlorins have strong long- wavelength absorptions > 800 nm, and were tested for in vivo photosensitizing activity using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. In preliminary screening, among the photosensitizers tested so far, bacteriochlorins (19) and (20) have shown promising anti-tumor activity. Preliminary attempts are described, using photo- Fenton chemistry, to synthesize photosensitizers which display both Type-I and Type-II photochemical behavior.

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Proceedings of SPIE - The International Society for Optical Engineering

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