Lignin-graft-PLGA drug-delivery system improves efficacy of MEK1/2 inhibitors in triple-negative breast cancer cell line

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Few targeted therapies are available for triple-negative breast cancer (TNBC) patients. Here, we propose a novel alkaline-lignin-conjugated-poly(lactic--glycolic acid) (L-PLGA) nanoparticle drug delivery system to improve the efficacy of targeted therapies. L-PLGA nanoparticles (NPs) loaded with the MEK1/2 inhibitor GDC-0623 were characterized, tested on MDA-MB-231 TNBC cell line and compared with loaded PLGA NPs. Loaded L-PLGA NPs were less than half the size of PLGA NPs, had slower drug release and improved the efficacy of GDC-0623 when tested . We demonstrated that GDC-0623 reversed epithelial-to-mesenchymal transition in TNBC. Our findings indicate that L-PLGA NPs are superior to PLGA NPs in delivering GDC-0623 to cancer cells for improved efficacy .

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Nanomedicine (London, England)

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