Document Type
Article
Publication Date
12-1-2015
Abstract
A continuous flow process for production of water-soluble Platinum-Dimercaptosuccinic acid (Pt(DMSA)) nanoparticles at ambient conditions using millifluidics is demonstrated. The process development was supported by in-situ synchrotron radiation-based X-ray absorption spectroscopy (XAS) investigations. The XAS revealed that the nucleation and growth of the Pt(DMSA) nanoparticles is extremely fast. Such a fast nucleation and growth process was also found to hinder coating of the channel walls, except at the zone 1 where the reactants first interact. The engineering of hitherto unreported Pt(DMSA) nanoparticles, well characterized using High-resolution transmission electron microscopy (HR-TEM), Scanning transmission electron microscopy (STEM), Scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), Powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infra-red spectroscopy (FT-IR), using continuous flow processes offers potential opportunities for scale-up.
Publication Source (Journal or Book title)
Chemical Engineering Journal
First Page
81
Last Page
86
Recommended Citation
Navin, C., Krishna, K., Bovenkamp-Langlois, G., Miller, J., Chattopadhyay, S., Shibata, T., Losovyj, Y., Singh, V., Theegala, C., & Kumar, C. (2015). Investigation of the synthesis and characterization of platinum-DMSA nanoparticles using millifluidic chip reactor. Chemical Engineering Journal, 281, 81-86. https://doi.org/10.1016/j.cej.2015.06.049