Cellular fate of delivery systems and entrapped bioactives

Document Type

Article

Publication Date

4-24-2015

Abstract

Nanoparticles (NPs) are a potentially beneficial delivery system for improving nutrient delivery. To fully take advantage of the nanodelivery systems for delivery of nutrients, it is important to understand the fate of the NPs and the entrapped bioactive, which will dictate the efficacy of the bioactive and the safety of the NP construct. The properties of the biological membranes and the physical-chemical characteristics of the nanodelivery systems will dictate the interaction of NPs with biological systems, and the fate of the NPs and entrapped bioactive. In molecular simulations, submolecular-level details of a system can be observed in order to gain insight into the behavior of a system or mechanism of a process. Optimization of NP properties improves delivery of the bioactive by offering several advantages: protection against degradation, controlled-release at the target of interest, and delivery to the cell compartment of interest.

Publication Source (Journal or Book title)

Nanotechnology and Functional Foods: Effective Delivery of Bioactive Ingredients

First Page

35

Last Page

51

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