Document Type
Article
Publication Date
6-1-2017
Abstract
In the recent years, engineered nanoparticles (NPs) such as PLGA or poly-lactic-co-glycolic acid, have raised a substantial interest due to their possible medical applications in vaccination, diagnostic imaging procedures, cancer therapy or sustained delivery of drugs. The main aim of the present work is to evaluate key oxidative stress parameters in several organs following NPs administration in an animal model. Our data shows that acute oral administration of PLGA NPs induces a change in the antioxidant status in both rat liver and spleen, but may not induce oxidative stress damage to cell structures such as lipid or protein oxidation.
Publication Source (Journal or Book title)
Materiale Plastice
First Page
249
Last Page
252
Recommended Citation
Miricescu, D., Stanescu, I., Perlea, P., Calenic, B., Radulescu, R., Totan, A., Virgolici, B., Sabliov, C., & Greabu, M. (2017). Oxidative stress following PLGA nanoparticles administration to an animal model. Materiale Plastice, 54 (2), 249-252. https://doi.org/10.37358/mp.17.2.4826