Document Type
Article
Publication Date
1-1-2005
Abstract
Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5′ and 3′ regions of the gene were significantly associated with ACE concentration (P < 10-4). Multi-locus genotypes comprising different combinations of markers from the 5′ UTR and the 3′ region of the gene were also analysed; in addition to G2350A, in the 3′ region, two markers from the 5′ UTR (A-5466C and A-240T) were found to be associated with ACE concentration. These results are consistent with reports that have suggested the presence of at least two ACE-linked QTLs, and demonstrate the utility of gamete competition models in the exploratory investigation of the relationship between a quantitative trait and multiple variants in a small genomic region. © University College London 2005.
Publication Source (Journal or Book title)
Annals of Human Genetics
First Page
227
Last Page
232
Recommended Citation
Mckenzie, C., Sinsheimer, J., Adeyemo, A., Cox, R., Southam, L., Hugill, A., Bouzekri, N., Lathrop, M., Forrester, T., Cooper, R., & Ward, R. (2005). SNP haplotypes in the Angiotensin I-converting Enzyme (ACE) gene: Analysis of Nigerian family data using gamete competition models. Annals of Human Genetics, 69 (2), 227-232. https://doi.org/10.1046/j.1469-1809.2004.00142.x