Influence of dietary L-camitine during experimentally-induced hyperammonemia in sheep fed diets containing Nonprotein Nitrogen (NPN)
The effect of supplemental dietary L-camitine during experimentally-induced hyperammonemia was investigated in 23 Suffolk lambs in a RBD. Lambs (77.4 kg BW) were individually fed diets containing two levels of dietary urea (0 or 50% of total N) and two levels of 50% L-camitine (0 or 454 g/ton) in a 2 x 2 factorial arrangement of treatments for 50 days. Subclinical hyperammonemia was induced using an oral urea load test (OULT; 835 mg/kg.75 BW) on days 10 (OULT1) and 50 (OULT2) of the trial. Blood was sampled via a jugular vein catheter for 420 min at various time intrevals. During the OULT1, plasma ammonia N and glucose were highest (P< .0001) in UREA+CARN compared with CONT, CARN, and UREA. During the OULT2, plasma ammonia N was highest (P < .0001) in UREA and UREA+CARN compared with CONT and CARN. Plasma glucose was lowest (P < .04) In UREA+CARN compared with UREA and CARN, but did not differ (P > .10) from CONT. Plasma urea N levels during both OULT1 and OULT2 were lower (P < .0001) in UREA and UREA+CARN compared with CONT and CARN. In the present experiment, adaptation to NPN influenced the response to induced hyperammonemia in sheep; however, supplemental L-camitine did not.
Publication Source (Journal or Book title)
Chapa, A., Fernandez, J., Bunting, L., Gentry, L., White, T., Hoover, D., Southern, L., & Blum, S. (1998). Influence of dietary L-camitine during experimentally-induced hyperammonemia in sheep fed diets containing Nonprotein Nitrogen (NPN). FASEB Journal, 12 (5) Retrieved from https://repository.lsu.edu/animalsciences_pubs/1110