An investigation of the role played by the superior colliculus and ventromedial thalamus in self-injurious behavior produced by intranigral microinjection of muscimol
Document Type
Article
Publication Date
1-1-1987
Abstract
Bilateral injection of muscimol (30 or 60 ng) into the substantia nigra (pars reticulata) of rats produced a variety of stereotyped acts, self-injurious behavior (SIB), and antinociception. Bilateral electrolytic lesions of the superior colliculus strongly suppressed SIB without reducing the antinociceptive effects of intranigral muscimol. Electrolytic lesions of the ventromedial thalamus had no effect on behavioral responses to intranigral muscimol. These studies suggest that the SIB produced by intranigral muscimol is mediated by neuronal pathways that terminate in or pass through the superior colliculus. The ventromedial thhalamus does not appear to play a role in mediating behavioral responses to intranigral muscimol. © 1987.
Publication Source (Journal or Book title)
Pharmacology, Biochemistry and Behavior
First Page
187
Last Page
189
Recommended Citation
Baumeister, A., Frye, G., & Moore, L. (1987). An investigation of the role played by the superior colliculus and ventromedial thalamus in self-injurious behavior produced by intranigral microinjection of muscimol. Pharmacology, Biochemistry and Behavior, 26 (1), 187-189. https://doi.org/10.1016/0091-3057(87)90553-3