Bilateral intranigral microinjection of morphine and opioid peptides produces antinociception in rats

Document Type

Article

Publication Date

5-12-1987

Abstract

Bilateral intranigral microinjection of morphine produced dose-related and naloxone-reversible antinociceptive effects on the tail-flick and hot-plate tests. Intranigral injection of enkephalin had antinociceptive effects on both tests, and dynorphin had an antinociceptive effect on the hot-plate test. This is the first report of evidence that nigral opiate receptors may mediate antinociception. © 1987.

Publication Source (Journal or Book title)

Brain Research

First Page

183

Last Page

186

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