Evidence for a supraspinal mechanism in the opioid-mediated antinociceptive effect of ketamine

Document Type

Article

Publication Date

12-6-1991

Abstract

Systemic ketamine (50 or 160 mg/kg, i.p.) produced an antinociceptive effect in rats on the tail flick test. This effect of ketamine was inhibited by injection of naloxone (27 nmol) into the lateral ventricle. Intrathecal ketamine (3 μm) produced a slight but significant antinociceptive effect on the tail flick test, which was not affected by injection of naloxone (27 nmol) into the lateral ventricle. Antinociception was not produced by injection of ketamine into the lateral ventricle (3 μm) or the rostral ventromedial medulla RVM (30 nmol). The role played by spinal and supraspinal opioid receptors in ketamine-induced antinociception is discussed. © 1991.

Publication Source (Journal or Book title)

Brain Research

First Page

351

Last Page

353

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