Novel epigenetic link between gestational diabetes mellitus and macrosomia
Document Type
Article
Publication Date
8-1-2021
Abstract
Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes IGF1, IGF2, H19, ARHGRF11, MEST, NR3C1, ADIPOQ and RETN. Materials & methods: A total of 1145 children (572 GDM cases and 573 controls) from the Tianjin GDM study, including 177 with macrosomia, had blood DNA collection at median age 5.9 (range: 3.1-10.0). We used logistic regression to screen for associations with GDM and model macrosomia on 37 CpGs, and performed mediation analysis. Results: One CpG was associated with macrosomia at false discovery rate (FDR) <0.05 (cg14428359 in MEST); two (cg19466922 in MEST and cg26263166 in IGF2) were associated at p < 0.05 but mediated 26 and 13%, respectively. Conclusion: MEST and IGF2 were previously identified for potential involvement in fetal growth and development (Trial Registration number: NCT01554358 [ClinicalTrials.gov]).
Recommended Citation
Joyce, B., Liu, H., Wang, L., Wang, J., Zheng, Y., Nannini, D., Drong, A., Shiau, S., Li, W., Leng, J., Shen, Y., Gao, R., Baccarelli, A., Hu, G., & Hou, L. (2021). Novel epigenetic link between gestational diabetes mellitus and macrosomia. Retrieved from https://repository.lsu.edu/pop_public_health_pubs/68