A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: Protocol and rationale of the Take a STAND for Health study

Authors

Ana Jessica Pinto, Universidade de São Paulo
Tiago Peçanha, Universidade de São Paulo
Kamila Meireles, Universidade de São Paulo
Fabiana Braga Benatti, Universidade de São Paulo
Karina Bonfiglioli, Universidade de São Paulo
Ana Lúcia De Sá Pinto, Universidade de São Paulo
Fernanda Rodrigues Lima, Universidade de São Paulo
Rosa Maria Rodrigues Pereira, Universidade de São Paulo
Maria Claudia Costa Irigoyen, Universidade de São Paulo
James Edward Turner, University of Bath, Department for Health
John P. Kirwan, Pennington Biomedical Research Center
Neville Owen, Baker Heart and Diabetes Institute
David W. Dunstan, Baker Heart and Diabetes Institute
Hamilton Roschel, Universidade de São Paulo
Bruno Gualano, Universidade de São Paulo

Document Type

Article

Publication Date

2-12-2020

Abstract

Background: Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed intervention focused on reducing sedentary time, and potential clinical, physiological, metabolic and molecular effects in rheumatoid arthritis. Methods: The Take a STAND for Health study is a 4-month, parallel-group, randomized controlled trial, in which postmenopausal patients with rheumatoid arthritis will set individually tailored, progressive goals to replace their sedentary time with standing and light-intensity activities. Patients will be recruited from the Clinical Hospital (School of Medicine, University of Sao Paulo) and will be assessed at baseline and after a 4-month follow up. Outcomes will include objectively measured sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition; aerobic fitness, muscle function, blood pressure, cardiovascular autonomic function, vascular function and structure, health-related quality of life, and food intake. Blood and muscle samples will be collected for assessing potential mechanisms, through targeted and non-targeted approaches. Discussion: Findings will be of scientific and clinical relevance with the potential to inform new prescriptions focused on reducing sedentary behavior, a modifiable risk factor that thus far has been overlooked in patients with rheumatoid arthritis. Trial registration: ClinicalTrials.gov, NCT03186924. Registered on 14 June 2017.

Recommended Citation

Pinto, A., Peçanha, T., Meireles, K., Benatti, F., Bonfiglioli, K., De Sá Pinto, A., Lima, F., Pereira, R., Irigoyen, M., Turner, J., Kirwan, J., Owen, N., Dunstan, D., Roschel, H., & Gualano, B. (2020). A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: Protocol and rationale of the Take a STAND for Health study. Retrieved from https://repository.lsu.edu/pbrc_basic_science_pubs/210