Chemical dispersants used in the Gulf of Mexico oil crisis are cytotoxic and genotoxic to sperm whale skin cells
Document Type
Article
Publication Date
7-1-2014
Abstract
The 2010 Deepwater Horizon oil rig explosion in the Gulf of Mexico drew attention to the need for toxicological studies of chemical dispersants. We are still learning the effects these spills had on wildlife. Little is known about the toxicity of these substances in marine mammals. The objective of this study was to determine the toxicity of the two dispersants (Corexit 9500 and 9527). Corexit 9500 and 9527 were both cytotoxic to sperm whale skin fibroblasts. Corexit 9527 was less cytotoxic than 9500. S9 mediated metabolism did not alter cytotoxicity of either dispersant. Both dispersants were genotoxic to sperm whale skin fibroblasts; S9 mediated metabolism increased Corexit 9527 genotoxicity. © 2014 Elsevier B.V.
Publication Source (Journal or Book title)
Aquatic Toxicology
First Page
335
Last Page
340
Recommended Citation
Wise, C., Wise, J., Wise, S., Thompson, W., Wise, J., & Wise, J. (2014). Chemical dispersants used in the Gulf of Mexico oil crisis are cytotoxic and genotoxic to sperm whale skin cells. Aquatic Toxicology, 152, 335-340. https://doi.org/10.1016/j.aquatox.2014.04.020