Document Type
Article
Publication Date
3-1-2012
Abstract
Health benefits of resistant starch (RS), a dietary fermentable fiber, have been well documented in young, but not in old populations. As the essential step of more comprehensive evaluations of RS on healthy aging, we examined the effects of dietary RS on tolerance, colonic fermentation, and cytokine expression in aged mice. Healthy older (18-20 months) C57BL/6J male mice were fed control, 18% RS, or 36% RS diets for 10weeks. Body weight gain, body composition, and fat pad weights did not differ among the three groups after 10weeks, indicating good tolerance of the RS diet. Fermentation indicators (cecum weights, and cecal proglucagon and PYY mRNA expression) were enhanced in an RS dose-dependent manner (p<0.01). Serum concentrations of soluble cytokine receptors (sTNF-Rb, sIL-4R, sIL-2Rα, sVEGFR1, and sRAGE) and TNFα expression (gene and protein) in visceral fat did not differ significantly among groups. Adiponectin protein concentrations, but not gene expression, were greater in epididymal fat of the 36% RS versus control groups (p<0.05). As a conclusion in aged mice, dietary RS is well tolerated, fermented in the colon, and stimulates colonic expression of proglucagon and PYY mRNA, and adiponectin protein in visceral fat. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication Source (Journal or Book title)
Molecular Nutrition and Food Research
First Page
515
Last Page
518
Recommended Citation
Zhou, J., Keenan, M., Keller, J., Fernandez-Kim, S., Pistell, P., Tulley, R., Raggio, A., Shen, L., Zhang, H., Martin, R., & Blackman, M. (2012). Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch. Molecular Nutrition and Food Research, 56 (3), 515-518. https://doi.org/10.1002/mnfr.201100521