On the Optimal Rate of freezing native and artificial tissues

Document Type

Conference Proceeding

Publication Date

12-1-2004

Abstract

The effect of several cell level parameters on the predicted optimal cooling rate (B opt) of an arbitrary biological system has been studied using a well-defined water transport model. The key cell level parameters investigated were, reference permeability of the membrane to water (L pg), apparent activation energy (E Lp), and the ratio of the available surface area for water transport to the initial volume of intracellular water (SA/WV). An exact and linear relationship exists between L pg, SA/WV and B opt. However, a nonlinear and inverse relationship is found between E Lp and B opt. These results are used to develop a Generic Optimal Cooling Rate Chart (GOCRC) and a Generic Optimal Cooling Rate Equation (GOCRE). © 2004 Materials Research Society.

Publication Source (Journal or Book title)

Materials Research Society Symposium Proceedings

First Page

5

Last Page

7

This document is currently not available here.

Share

COinS