Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds
Document Type
Conference Proceeding
Publication Date
1-1-2012
Abstract
Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined. Copyright © 2012 by ASME.
Publication Source (Journal or Book title)
ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
First Page
651
Last Page
656
Recommended Citation
Chinnasami, H., Idicula, G., Hayes, D., & Devireddy, R. (2012). Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), 2, 651-656. https://doi.org/10.1115/IMECE2012-87558