Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions
Document Type
Conference Proceeding
Publication Date
12-1-2013
Abstract
Poly (l-lactic acid) (PLLA) scaffolds for bone grafts were prepared by using Thermally Induced Phase Separation (TIPS) method. Solutions of PLLA-dioxane was formed by dissolving a predetermined value of PLLA in dioxane (3, 7 and 10% wt/vol) at 323K. These solutions were frozen at controlled cooling rates (1, 10 and 40°C/min) in cylindrical capsules. The frozen solutions were freeze-dried for a period of 48 hours for the frozen dioxane to completely sublimate, leaving the porous PLLA scaffold. The scaffolds which were formed under different processing conditions were characterized in terms of porosity, pore sizes and compressive moduli. Copyright © 2013 by ASME.
Publication Source (Journal or Book title)
ASME 2013 Summer Bioengineering Conference, SBC 2013
Recommended Citation
Chinnasami, H., Hayes, D., & Devireddy, R. (2013). Synthesis of poly (L-lactic acid) scaffolds under controlled freezing conditions. ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 A https://doi.org/10.1115/SBC2013-14168