Transport of single molecules through nanochannels: A novel approach to DNA sequencing
Document Type
Conference Proceeding
Publication Date
1-1-2009
Abstract
Understanding the transport dynamics of single molecules through 1D and 2D nano-channels is a fundamental prerequisite toward designing high-throughput systems for DNA sequencing. Our efforts are focused on the fabrication of the prerequisite structures using replication technology to produce both nano- and micro-scale channels in polymeric substrates with the size of these channels equal to or less than the persistence length of a dsDNA biopolymer. Molecular dynamics is being used to study the transport of DNA mononucleotides through 1D molecular-scale channels for identification. © 2009 CBMS.
Publication Source (Journal or Book title)
Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
First Page
177
Last Page
179
Recommended Citation
Chantiwas, R., Hupert, M., López, J., Datta, P., Gottert, J., Novak, B., Moldovan, D., Jha, S., Park, S., Murphy, M., Nikitopoulos, D., & Soper, S. (2009). Transport of single molecules through nanochannels: A novel approach to DNA sequencing. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 177-179. Retrieved from https://repository.lsu.edu/mechanical_engineering_pubs/1740