Nanogap electrical detection of single molecules translocating through a nanochannel with transverse nanoelectrodes and funnels populated with an array of nanopillars
Document Type
Conference Proceeding
Publication Date
12-1-2011
Abstract
We are developing techniques for the fabrication of mixed-scale systems (nm to mm) used for the molecular-scale sensing of single-molecules (DNAs, RNAs, peptides and proteins). The system consists of microchannels and nanochannels (10-100 nm) with integrated electrodes of similar dimensions for transducing single molecules. The system is applicable for the rapid and efficient sequencing of biopolymers by measuring flight-times of monomer units clipped from a single polymer. Preliminary results from calculations and Molecular Dynamic (MD) simulations have supported the viability of our system. Copyright © (2011) by the Chemical and Biological Microsystems Society.
Publication Source (Journal or Book title)
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
First Page
401
Last Page
403
Recommended Citation
Uba, F., Wu, J., Park, S., Moldovan, D., Novak, B., Shin, H., Park, D., Cho, Y., Kim, T., & Soper, S. (2011). Nanogap electrical detection of single molecules translocating through a nanochannel with transverse nanoelectrodes and funnels populated with an array of nanopillars. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 1, 401-403. Retrieved from https://repository.lsu.edu/mechanical_engineering_pubs/1737