Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight management

Hiba Jebeile, The University of Sydney
Natalie B. Lister, The University of Sydney
Sol Libesman, The University of Sydney
Kylie E. Hunter, The University of Sydney
Caitlin M. McMaster, The University of Sydney
Brittany J. Johnson, Caring Futures Institute
Louise A. Baur, The University of Sydney
Susan J. Paxton, La Trobe University
Sarah P. Garnett, The University of Sydney
Amy L. Ahern, MRC Epidemiology Unit
Denise E. Wilfley, Washington University in St. Louis
Sarah Maguire, Faculty of Medicine and Health
Amanda Sainsbury, The University of Western Australia
Katharine Steinbeck, The University of Sydney
Lisa Askie, The University of Sydney
Caroline Braet, Universiteit Gent
Andrew J. Hill, University of Leeds, School of Medicine
Dasha Nicholls, Imperial College London
Rebecca A. Jones, MRC Epidemiology Unit
Genevieve Dammery, Faculty of Medicine and Health
Alicia M. Grunseit, The Children's Hospital at Westmead
Kelly Cooper, Weight Issues Network
Theodore K. Kyle, ConscienHealth
Faith A. Heeren, University of Florida College of Medicine
Fiona Quigley, Ulster University
Rachel D. Barnes, University of Minnesota Medical School
Melanie K. Bean, VCU School of Medicine
Kristine Beaulieu, Faculty of Medicine and Health
Maxine Bonham, Monash University
Kerri N. Boutelle, Department of Pediatrics
Braulio Henrique Magnani Branco, Universidade UniCesumar
Simona Calugi, Villa Garda Hospital
Michelle I. Cardel, University of Florida College of Medicine
Kelly Carpenter, Optum, Inc.

Document Type

Article

Publication Date

7-1-2023

Abstract

The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. We present a protocol for a systematic review and individual participant data (IPD) meta-analysis which aims to identify participants at risk of developing eating disorders, or related symptoms, during or after weight management interventions conducted in adolescents or adults with overweight or obesity. We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. Authors from eligible trials have been invited to share their deidentified IPD. Two IPD meta-analyses will be conducted. The first IPD meta-analysis aims to examine participant level factors associated with a change in eating disorder scores during and following a weight management intervention. To do this we will examine baseline variables that predict change in eating disorder risk within intervention arms. The second IPD meta-analysis aims to assess whether there are participant level factors that predict whether participation in an intervention is more or less likely than no intervention to lead to a change in eating disorder risk. To do this, we will examine if there are differences in predictors of eating disorder risk between intervention and no-treatment control arms. The primary outcome will be a standardised mean difference in global eating disorder score from baseline to immediately post-intervention and at 6- and 12- months follow-up. Identifying participant level risk factors predicting eating disorder risk will inform screening and monitoring protocols to allow early identification and intervention for those at risk.

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