Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol

Authors

John M. Jakicic, University of Kansas Medical Center
Wendy M. Kohrt, University of Colorado Anschutz Medical Campus
Joseph A. Houmard, East Carolina University
Michael E. Miller, Wake Forest University School of Medicine
Shlomit Radom-Aizik, University of California, Irvine
Blake B. Rasmussen, The University of Texas Health Science Center at San Antonio
Eric Ravussin, Pennington Biomedical Research Center
Monica Serra, The University of Texas Health Science Center at San Antonio
Cynthia L. Stowe, Wake Forest University School of Medicine
Scott Trappe, Ball State University
Hiba Abouassi, Duke University
Joshua N. Adkins, Oregon Health & Science University
D. Lee Alekel, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Euan Ashley, Stanford University
Marcas M. Bamman, The University of Alabama at Birmingham
Bryan C. Bergman, University of Colorado Anschutz Medical Campus
Daniel H. Bessesen, University of Colorado Anschutz Medical Campus
Nicholas T. Broskey, East Carolina University
Thomas W. Buford, The University of Alabama at Birmingham
Charles F. Burant, University of Michigan, Ann Arbor
Haiying Chen, Wake Forest University School of Medicine
Jeffrey W. Christle, Stanford University
Clary B. Clish, Broad Institute
Paul M. Coen, AdventHealth Translational Research Institute
David Collier, East Carolina University
Katherine A. Collins, Duke University
Daniel M. Cooper, University of California, Irvine
Tiffany Cortes, The University of Texas Health Science Center at San Antonio
Gary R. Cutter, University of Alabama at Birmingham School of Public Health
Gabriel Dubis, East Carolina University
Facundo M. Fernández, Georgia Institute of Technology
Jonathon Firnhaber, East Carolina University
Daniel E. Forman, University of Pittsburgh
David A. Gaul, Georgia Institute of Technology

Document Type

Article

Publication Date

9-1-2024

Abstract

Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of these molecular responses to exercise has not been developed. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a multicenter study designed to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. MoTrPAC contains both a preclinical and human component. The details of the human studies component of MoTrPAC that include the design and methods are presented here. The human studies contain both an adult and pediatric component. In the adult component, sedentary participants are randomized to 12 wk of Control, Endurance Exercise Training, or Resistance Exercise Training with outcomes measures completed before and following the 12 wk. The adult component also includes recruitment of highly active endurance-trained or resistance-trained participants who only complete measures once. A similar design is used for the pediatric component; however, only endurance exercise is examined. Phenotyping measures include weight, body composition, vital signs, cardiorespiratory fitness, muscular strength, physical activity and diet, and other questionnaires. Participants also complete an acute rest period (adults only) or exercise session (adults, pediatrics) with collection of biospecimens (blood only for pediatrics) to allow for examination of the molecular responses. The design and methods of MoTrPAC may inform other studies. Moreover, MoTrPAC will provide a repository of data that can be used broadly across the scientific community. NEW & NOTEWORTHY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will be the first large trial to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. By generating a compendium of the molecular responses to exercise, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. Presented here is the design, protocols, and procedures for the MoTrPAC human studies.

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