An expedient synthesis of functionalized 1,4-diketone-derived compounds via silyloxyallyl cation intermediates
© The Royal Society of Chemistry 2016. Herein we describe a new method, enabling the synthesis of highly functionalized 1,4-diketones that are readily differentiated as monosilylenol ethers under Brønsted acid catalysis. This synthetically useful chemistry exploited an intermediacy of unsymmetrical silyloxyallyl cations, which were directly captured by silyl enolates to create the targeted α,α carbon-carbon linkages in a regioselective manner. Our reaction conditions proved to be mild, rendering the silylenol ether functionalities intact.
Publication Source (Journal or Book title)
Stepherson, J., Fronczek, F., & Kartika, R. (2016). An expedient synthesis of functionalized 1,4-diketone-derived compounds via silyloxyallyl cation intermediates. Chemical Communications, 52 (11), 2300-2303. https://doi.org/10.1039/c5cc09763k