A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported. © 1994 American Society for Mass Spectrometry.
Publication Source (Journal or Book title)
Journal of the American Society for Mass Spectrometry
Murray, K., & Russell, D. (1994). Aerosol Matrix-Assisted Laser Desorption Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 5 (1), 1-9. https://doi.org/10.1016/1044-0305(94)85077-1