Optimal strategies for controlling particle size in antisolvent crystallization operations

Document Type

Conference Proceeding

Publication Date

1-1-2007

Abstract

In this paper, a model-based optimal strategy is presented for the control of particle size in antisolvent crystallization. Size is controlled on demand by dynamic optimization using a population balance based model. Knowledge of the ternary solutesolvent-antisolvent equilibrium and crystallization kinetics is crucial in this strategy and are both experimentally identified and incorporated in the model. The optimization is capable of determining the optimal antisolvent feed profile that achieves a desired particle size. Experimental validation of the strategy is carried out and presented herein. Such a strategy stands as a key solution to antisolvent operations ubiquitous in the pharmaceutical and fine chemicals industries.

Publication Source (Journal or Book title)

IFAC Proceedings Volumes (IFAC-PapersOnline)

First Page

177

Last Page

182

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