Comparison of the use of different solubility models for the cooling crystallization of acetaminophen
Document Type
Conference Proceeding
Publication Date
12-1-2008
Abstract
In this paper we evaluate the sensitivity of using different solubility models on the cooling crystallization of acetaminophen. Empirical, correlative thermodynamic (namely NRTL) and predictive thermodynamic (namely MOSCED) models are considered. Equilibrium solubility model prediction determines the predicted supersaturation profile. The different solubility equations are used within a population balance model for prediction of crystal size properties. Incorrect prediction of the supersaturation profile results in incorrect prediction of crystal size distribution. The NRTL model was found to be more accurate at predicting equilibrium solubility and consequently crystal size. After the solubility sensitivity is evaluated, two methods are proposed to make the crystallization model more robust against solubility model errors.
Publication Source (Journal or Book title)
AIChE Annual Meeting, Conference Proceedings
Recommended Citation
Widenski, D., Abbas, A., & Romagnoli, J. (2008). Comparison of the use of different solubility models for the cooling crystallization of acetaminophen. AIChE Annual Meeting, Conference Proceedings Retrieved from https://repository.lsu.edu/chem_engineering_pubs/621