Waste-reducing catalysis for acylation of a secondary amine: Synthesis of DEET

Document Type

Article

Publication Date

11-1-2004

Abstract

Mixed oxide catalysts were studied for a model acylation - m-toluic acid reacting with diethylamine to N,N-diethyl-3-methylbenzamide (DEET) - and compared to standard homogeneous catalysts such as titanium chelates. More acidic catalysts such as hydroxyapatites and supported 12-tungstophosphates were active, stable in a gas phase, and selective with stoichiometric feeds. Optimal results (long-term MTA conversion of 78 ± 6%, DEET selectivity of 86 ± 3% at WHSV = 3-9 h -1, no deactivation over 100 h) were obtained with a supported 12-tungstophosphate at 573 K, 0.1 MPa.

Publication Source (Journal or Book title)

Catalysis Letters

First Page

69

Last Page

75

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