Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity

Authors

Konstantin G. Kousoulas, Pennsylvania State University
David J. Bzik, Pennsylvania State University
Stanley Person, Pennsylvania State University

Document Type

Article

Publication Date

1-1-1983

Abstract

The ionophore monensin inhibited the formation of mature, fully glycosylated glycoproteins gB, gC, and gD during herpes simplex virus type 1 infection of human embryonic lung cells. Underglycosylated forms, including the apparent high-mannose precursor forms of the major glycoproteins, appeared. Monensin inhibited virus-induced cell fusion. Infectious virions produced in the presence of monensin appeared to contain predominantly underglycosylated glycoproteins. © 1983 S. Karger AG, Basel.

Publication Source (Journal or Book title)

Intervirology

First Page

56

Last Page

60

Recommended Citation

Kousoulas, K., Bzik, D., & Person, S. (1983). Effect of the ionophore monensin on herpes simplex virus Type 1-induced cell fusion, glycoprotein synthesis, and virion infectivity. Intervirology, 20 (1), 56-60. https://doi.org/10.1159/000149375