Truncation of the carboxy-terminal 28 amino acids of glycoprotein B specified by herpes simplex virus type 1 mutant amb1511-7 causes extensive cell fusion
Document Type
Article
Publication Date
1-1-1993
Abstract
Three amber mutations were introduced proximal to the syn3 locus of the herpes simplex virus type 1 glycoprotein B (gB) gene specifying gB derivatives lacking the carboxy-terminal 28, 49, or 64 amino acids. A complementation system that utilized gBs expressed in COS cells to complement gB-null virus KΔT was established. The 49- or 64-amino-acid-truncated gBs failed to complement gB-null virus KΔT, while the 28-amino-acid-truncated gB complemented KΔT efficiently. Mutant herpes simplex virus type 1 KOS (amb1511-7) specifying the 28-amino-acid-truncated gB fused Vero cells extensively.
Publication Source (Journal or Book title)
Journal of Virology
First Page
2396
Last Page
2401
Recommended Citation
Baghian, A., Huang, L., Newman, S., Jayachandra, S., & Kousoulas, K. (1993). Truncation of the carboxy-terminal 28 amino acids of glycoprotein B specified by herpes simplex virus type 1 mutant amb1511-7 causes extensive cell fusion. Journal of Virology, 67 (4), 2396-2401. Retrieved from https://repository.lsu.edu/animalsciences_pubs/2252