Serotonin-induced increases in platelet cytosolic calcium concentration in depressed, schizophrenic, and substance abuse patients

Document Type

Article

Publication Date

4-15-1996

Abstract

Exaggerated intracellular calcium responses to challenges with serotonin (5-HT) have been reported in depression, In our studies, consistent with previous reports, patient,F with depression exhibited an exaggerated increase in 5-HT-stimulated intracellular calcium concentration ([Ca++](i)). Basal cytosolic calcium was elevated in both calcium-free and 1 mM calcium media in depressed patients. The increased responsiveness to 5-HT was seen in both conditions. Patients with schizophrenia and substance abuse did not differ from normal controls. The 5-HT response was correlated with diastolic blood pressure (r = 0.33, p = 0.02): however, this association did not fully account for the exaggerated [Ca++](i) responses in the depressed group. These findings suggest that exaggerated increases in [Ca++](i) in response to serotonin are a characteristic of depressed patients not shared with schizophrenic and substance abuse patients. The relationship of-depression to hypertension, two conditions that share abnormalities of calcium homeostasis, warrants further study.

Publication Source (Journal or Book title)

Biological Psychiatry

First Page

708

Last Page

713

This document is currently not available here.

Share

COinS