Document Type
Article
Publication Date
2-1-2003
Abstract
Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension in all populations. © 2003 American Journal of Hypertension, Ltd.
Publication Source (Journal or Book title)
American Journal of Hypertension
First Page
144
Last Page
147
Recommended Citation
Province, M., Kardia, S., Ranade, K., Rao, D., Thiel, B., Cooper, R., Risch, N., Turner, S., Cox, D., Hunt, S., Weder, A., & Boerwinkle, E. (2003). A meta-analysis of genome-wide linkage scans for hypertension: The National Heart, Lung and Blood Institute Family Blood Pressure Program. American Journal of Hypertension, 16 (2), 144-147. https://doi.org/10.1016/S0895-7061(02)03248-X