Ciprofloxacin treatment eliminates mycoplasma in contaminated channel catfish ovary cells
A temperature-sensitive mycoplasma that was present in the channel catfish ovary (CCO) cell line and in a thymidine kinase-negative mutant of this cell line (CCOBr) was effectively eliminated from the cultures by adding ciprofloxacin, a 4-fluoroquinolone, to the culture medium. Both cell lines have remained mycoplasma free after 3 years of continuous culture. A commercially available genetic probe to mycoplasma ribosomal RNA was used to monitor mycoplasma contamination and evaluate the effectiveness of the treatment. © by the American Fisheries Society 1994.
Publication Source (Journal or Book title)
Journal of Aquatic Animal Health
Hanson, L., & Thune, R. (1994). Ciprofloxacin treatment eliminates mycoplasma in contaminated channel catfish ovary cells. Journal of Aquatic Animal Health, 6 (1), 82-84. https://doi.org/10.1577/1548-8667(1994)006<0082:CTEMIC>2.3.CO;2