Phencyclidine in combination with pentobarbital: Supra-additive effects on complex operant behavior in pigeons

Document Type

Article

Publication Date

1-1-1982

Abstract

Pigeons acquired a different four-response chain each session by responding sequentially on three keys in the presence of four colors. The response chain was maintained by food presentation under afixed ration schedule. Errors produced a brief timeout but did not reset the chain. When phencyclidine was administered alone, the overall response rate decreased and the percent errors increased with increasing doses. Similar effects were found with a high dose of pentobarbital alone. When phencyclidine was administered in combination with pentobarbital dose-effect curves for rate and accuracy shifted to the left as the dose of pentrobarbital was increased. Cobinations of phencyclidine with a high dose of pentobarbital produced supra-additive effects;i.e., the effects on rate and accuracy were greater than expected from simple addition of the effects of each drug given alone. These results extend the generality of previous findings in patas monkeys in a similar repeated-acquisition task. © 1982.

Publication Source (Journal or Book title)

Pharmacology, Biochemistry and Behavior

First Page

353

Last Page

357

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