A histological study of the effect of saline and povidone-iodine infusions on the equine endometrium

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A study was conducted to assess the reaction of the endometrium of the mare to both saline and povidone-iodine infusions. In the control group (Group 1), uterine biopsies were taken at 0, 3, 5, 7, 10, 15, 20 and 30 days from the beginning of the experimental period. The treatment groups had intrauterine infusions of saline (Group 2) or 1% povidone iodine in saline (Group 3) on Days 0 and 2, and had endometrial biopsies taken on the same days as the control group. The concentration of inflammatory cells in the endometria of the Group-2 mares paralleled that of the Group-1 mares but was at a slightly higher level. Group-3 mares demonstrated significant increases in the numbers of inflammatory cells. An acute reaction was observed in Group-3 mares until Days 7 to 10. Thereafter, the inflammatory reaction changed in nature from an acute to a more chronic reaction. By Days 15 to 30, Group 3 still demonstrated increased signs of inflammation, including infiltration with eosinophils. The results of this study indicate that intrauterine infusion of 1% povidone-iodine solution in mares can cause chronic inflammatory changes in the endometrium. © 1992.

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